Despite the setback, Sampras thinks he can win the U.S. Open.
"You have to remember who I am and where I'm playing next week. The U.S. Open is where you shine, and that is where I hope to shine," said Sampras, who was seeded third here. "I'm not the man to beat like I once was - Lleyton Hewitt has taken that role. But I'm still one of the favorites.
"The days of me dominating and being No. 1 are probably over. My goal is to win another major and, hopefully, destiny will be on my side at the Open. It just takes one close win and things can turn around quickly."
Last year's runner-up here, Sampras has not reached the quarterfinals of any event since appearing in the final of the U.S. Men's Clay Court Championships in May. He has not won a title since Wimbledon 2000.