If the USO gets speed up massively or Wimbledon returns to its late 90s-speed-level, he'd have a chance at a big final. But this is unlikely to happen the next few years and even if it does, Isner's already turning 28 this year, he's probably past his prime. I think with a very, very favorable draw and massive crowd support, he could just get to the semis in New York, but definitely no further. And he'd also need his very best form just to get this far. Perhaps he's already wasted this chance in 2011. He's just not slam final material anyway, by any means.