Re: Will John Isner ever win anything big?
Hard court series.
The current greatness league of active players in order of achievements to date (a factual comparison rather than fan biased assessment):
Federer 17 GS, 6 Year End Masters, 23 Master Series.
Nadal 14 GS, 27 Master Series, 1 Olympic Gold.
Djokovic 7 GS, 4 Year End Masters, 20 Master Series.