I think Roger will prevail in a quite tough match.
It's true that Roddick has made a great comeback winning Cincinnati and reaching the final in the US Open thanks to Connors. He's more patient from the baseline, uses his sliced back hand more and coming to the net more. Plus, he's on fire and very motivated. However, Roger has a real gift in reading Roddick's serve. Plus, if Roger serves well, I don't see how Roddick can win. In addition, from the baseline, Roger is better with a better forehand and backhand too. Roger will win!