Unless you've been living under a rock, you know tennis has been dominated by three men for the better part of the past decade, Federer, Nadal and Djokovic, who hold a combined 34 Slams and counting and an incredible amoung of weeks at #1 (basically ever since Federer became #1 after AO 2004).
Up until this Friday, the only men to beat all three of them in Grand Slam events was Tsonga, but with his win over Federer Murray has joined him
Update: Berdych joins the club after beating Nadal at AO 2015!
Active players only one win away from doing this include:
Del Potro - needs a win over Djokovic
Soderling - needs a win over Djokovic
Hewitt - needs a win over Federer