It can be a very interesting match. Isner could beat Nadal but, being honest, it would be really hard for Isner to win, but I think it depends on whether Nadal plays well or just pushing.
I agree. Isner has a big serve and some incredible groundstrokes for his height. This is Nadal's worst match up. But then again Isner dosen't have Del Potro's talent nor consistency.
First set will be very important. If Nadal wins it then the match wiil be over, if not Nadal will have to bring his A game.