For Tsonga, the worst matchups are:
-great returners with strong baseline games - Djokovic and Murray basically. Jo's horrendous ROS makes him very reliant on his awesome serve, against players who can not only get it back but force him into long rallies and expose his iffy BH he's in trouble. Off clay, he WILL definitely beat Murray and Djokovic on the rare days where his BH and return are working to at least a decent level (ie not taking return games and leaking BH errors for fun), but on an average he's in trouble, hasn't beaten them for a long time. He's 1-6 vs Murray and lost the Wimbledon semi because despite having a far bigger/better serve Murray can do a lot more damage on return, Jo sturggles to get even Murray's powderpuff second serves back in play most times let alone with any bite.
-big hitters/servers. Because of the same issues: horrendous ROS, weak BH. Against guys who hit even bigger than him (Soderling, Del Potro) and can thus wrestle the initiative from him in most points, he's in trouble as his defense off the BH side is terrible as is his ROS, hence 0-5 vs Soderling and 2-5 vs Delpo (with the two wins coming with Delpo clearly diminished physically). Big servers (Isner, Raonic, Karlovic) because of his shit ROS of course.
Basically, all of Jo's matchup issues can be pinpointed to his BH and/or ROS. If he could somehow work on those aspects and make them at least solid, he'd very tough to beat for anyone and a Slam winner for sure.
yes except for big hitters, actually the main reason why Del Po wins against him is that he makes less errors and has a better backhand, like Söderling. Like Söderling he's just a better player than Tsonga. Also I disagree that on a good day, Tsonga wil definitely defeat Murray and Djokovic, he needs a very good day and them not to be at their top.
Against big serves first Tsonga returns bad, secondly he can always have an awol service game which is very costly in the end.
Also the passing-shot is very useful against him because he often goes to the net, hence why Murray is even a worse match-up for him than Djokovic.