Whereas I'm going with my extensive knowledge of results differences between men and women in measurable physical sports such as track-and-field, weight lifting, swimming and track cycling and saying she has no chance whatsoever.
But this isn't any of those sports. This is Tennis...maybe it's the fact I just seriously started to get into it, because of Federer/Nadal/Djokovic (sorry for my previous typo) rivalry, but aside from spin, a little bit more power and speed, and monster serves, I don't see much of a difference between men and women. Those factors may be enough to destroy Serena, but I can't see a 16 yo boy hitting the ball so hard that she can't return it. Remember this isn't any regular WTA player, this is Serena.
When I went to the US Open last year, frankly I only saw the men a few degrees above the women. I feel Tennis is more of a mental game if anything. I mainly watch American Football & Basketball so I know physically no woman can compete, but those are contact sports. Tennis is more about the mind. Again seeing games in person, I only saw a few degrees of difference between the men and the women. Maybe is my untrained eye, still learning about the sport.