It's possible but they will have to work a lot harder.
Nole had better preparations for this year's AO than the previous two years.
Good chance at AO (20%) (30%-Nad 30%-Fed 10%-Murray 10%-Sod)
Small chance at RG (10%)(75%-Nad 10%-Sod 4%-Fed 1%-Monfils)
Very small chance at Wimbledon (5%)
Great chance at USO (25%)
I don't give Soderling much chance here, he never does that well in Australia.
Nole is just behind Nadal, and let's say Federer, for this AO.
If he keeps his form and plays his cards right he could be the top favourite for the USO, considering how well he's always done there. It's between him and Federer IMO.
Wimbledon, don't have much hopes.
RG, no chance of beating Nadal, other than that he could do very well.